|
KMID : 0984920140160020106
|
|
Journal of Skin Barrier Research
2014 Volume.16 No. 2 p.106 ~ p.106
|
|
|
Evaluation of Anti-inflammatory Activity of N-Oleoylethanolamine (NOE) as a Topical Agent
|
|
Lee Seung-Hee
Kim Kkot-Byeol
Jang Mi-Jin
Lee Sun-A
Ahn Sung-Ku
Jeong Se-Kyoo
Hong Seung-Phil
Kim Hyun-Jung
|
|
|
Abstract
|
|
|
|
Biological activities of NOE (N-oleoylethanolamine) encompass inhibiting the ceramidase activity and stimulating serine palmitoyl transferase (SPT), which is a key enzyme for in situ ceramide synthesis. As a result, treatment of NOE induces accumulation of ceramide in cells. Previously, it was reported that treatment of NOE on cultured normal human epidermal keratinocyte (NHEK) resulted in the increased expression of the differentiation marker proteins, including involucrin and transglutaminase-1, which suggest a potential application of NOE for normalizing the hyper proliferation in inflammatory skin diseases. We have also reported that the topical application of cannabinoid receptor 1 (CB1R) agonist alleviated the inflammatory symptoms in atopic dermatitis animal model. Based on the structural similarity between NOE and previously reported CB1 agonist, it is hypothesized that topical application of NOE can be a therapeutic candidate for atopic dermatitis, at least in part, through the activation of CB1R. As results, topical application of NOE significantly accelerated the epidermal permeability barrier recovery after acute disruption. Anti-inflammatory activity of NOE was also observed in both TPA-induced acute dermatitis model and oxazolone-induced atopic dermatitis animal model, which was also confirmed by histological assessment. It also downregulated the expression of TSLP. These results suggest that, NOE can be used as an anti-inflammatory agents for skin diseases including atopic dermatitis.
|
|
|
KEYWORD
|
|
|
N-Oleoylethanolamine, thymic stromal lymphopoietin, atopic dermatitis, Cannabinoids
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|